Foam Cells Control Mycobacterium tuberculosis Infection

Latent Mycobacterium tuberculosis Infection.

To the Editor: In their review article, Getahun et al. (May 28 issue)1 provide a useful overview of issues surrounding latent tuberculosis infection. However, newly published data regarding the performance of the T-SPOT.TB assay call into question the supposition that false conversions and reversions are more common with interferon-γ release assays (IGRAs) than with tuberculin skin tests.2 Spec...

Is Critical for Host Control of Chronic Mycobacterium tuberculosis Infection

The role of dendritic cells in Mycobacterium tuberculosis infection

The immune response against Mycobacterium tuberculosis is multifactorial, involving a network of innate and adaptive immune responses. Characterization of the immune response, a clear understanding of the dynamics and interplay of different arms of the immune response are critical to allow the development of better tools for combating tuberculosis. Dendritic cells (DCs) are one of the key cells...

Gr1intCD11b+ Myeloid-Derived Suppressor Cells in Mycobacterium tuberculosis Infection

BACKGROUND Tuberculosis is one of the world's leading killers, stealing 1.4 million lives and causing 8.7 million new and relapsed infections in 2011. The only vaccine against tuberculosis is BCG which demonstrates variable efficacy in adults worldwide. Human infection with Mycobacterium tuberculosis results in the influx of inflammatory cells to the lung in an attempt to wall off bacilli by fo...

Control of chronic mycobacterium tuberculosis infection by CD4 KLRG1- IL-2-secreting central memory cells.

The bacille Calmette-Guérin vaccine provides very efficient protection in standard animal models of Mycobacterium tuberculosis challenge. We show in this article that although bacille Calmette-Guérin controlled M. tuberculosis growth for 7 wk of infection, the protection was gradually lost as the infection entered the chronic phase. The regrowth of M. tuberculosis coincided with an almost compl...